Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray, W J; Yao, M; Mumm, J; Schroeter, E H; Saftig, P; Wolfe, M; Selkoe, D J; Kopan, R; Goate, A M

Ray, W J; Yao, M; Mumm, J; Schroeter, E H; Saftig, P; Wolfe, M; Selkoe, D J; Kopan, R; Goate, A M.

Affiliation

Ray WJ; Departments of Psychiatry and Genetics, Washington University Medical School, St. Louis, Missouri 63110, USA.

J Biol Chem ; 274(51): 36801-7, 1999 Dec 17.

Article in En | MEDLINE | ID: mdl-10593990

Subject(s)

Endopeptidases/metabolism; Membrane Proteins/metabolism; Signal Transduction; 3T3 Cells; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Endopeptidases/genetics; Humans; Membrane Proteins/genetics; Mice; Mutation; Presenilin-1; Receptors, Cell Surface/metabolism; Receptors, Notch

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Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Signal Transduction / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 1999 Document type: Article

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