The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

Bai, D; Pennefather, P S; MacDonald, J F; Orser, B A

Bai, D; Pennefather, P S; MacDonald, J F; Orser, B A.

Affiliation

Bai D; Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

J Neurosci ; 19(24): 10635-46, 1999 Dec 15.

Article in En | MEDLINE | ID: mdl-10594047

Subject(s)

Anesthetics, General/pharmacology; Propofol/pharmacology; Receptors, GABA-A/drug effects; Receptors, GABA-A/metabolism; Animals; Cells, Cultured; Computer Simulation; Electric Conductivity; Kinetics; Mice; Models, Neurological; Patch-Clamp Techniques; Receptors, GABA-A/physiology; Time Factors; gamma-Aminobutyric Acid/administration & dosage; gamma-Aminobutyric Acid/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propofol / Receptors, GABA-A / Anesthetics, General Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 1999 Document type: Article

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