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Determination of oxygen extraction ratios by magnetic resonance imaging.
Oja, J M; Gillen, J S; Kauppinen, R A; Kraut, M; van Zijl, P C.
Affiliation
  • Oja JM; Department of Radiology, Johns Hopkins University Medical School, Baltimore, Maryland 21205, USA.
J Cereb Blood Flow Metab ; 19(12): 1289-95, 1999 Dec.
Article in En | MEDLINE | ID: mdl-10598932
ABSTRACT
The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T2 of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.
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Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxygen Consumption / Brain / Magnetic Resonance Imaging / Cerebrovascular Circulation Limits: Humans Language: En Journal: J Cereb Blood Flow Metab Year: 1999 Document type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Oxygen Consumption / Brain / Magnetic Resonance Imaging / Cerebrovascular Circulation Limits: Humans Language: En Journal: J Cereb Blood Flow Metab Year: 1999 Document type: Article