Antibodies against the first Ig-like domain of human platelet endothelial cell adhesion molecule-1 (PECAM-1) that inhibit PECAM-1-dependent homophilic adhesion block in vivo neutrophil recruitment.

Nakada, M T; Amin, K; Christofidou-Solomidou, M; O'Brien, C D; Sun, J; Gurubhagavatula, I; Heavner, G A; Taylor, A H; Paddock, C; Sun, Q H; Zehnder, J L; Newman, P J; Albelda, S M; DeLisser, H M

Nakada, M T; Amin, K; Christofidou-Solomidou, M; O'Brien, C D; Sun, J; Gurubhagavatula, I; Heavner, G A; Taylor, A H; Paddock, C; Sun, Q H; Zehnder, J L; Newman, P J; Albelda, S M; DeLisser, H M.

Affiliation

Nakada MT; Centocor, Malvern, PA 19355, USA.

J Immunol ; 164(1): 452-62, 2000 Jan 01.

Article in En | MEDLINE | ID: mdl-10605042

Subject(s)

Antibodies, Monoclonal/pharmacology; Immunoglobulins/immunology; Neutrophil Activation/immunology; Peptide Fragments/immunology; Platelet Endothelial Cell Adhesion Molecule-1/immunology; Amino Acid Sequence; Animals; Antibodies, Monoclonal/biosynthesis; Antibodies, Monoclonal/metabolism; Binding Sites, Antibody; Binding, Competitive; Cattle; Cell Adhesion/immunology; Cell Aggregation/immunology; Cell Movement/immunology; Endothelium, Vascular/immunology; Endothelium, Vascular/metabolism; Epitope Mapping; Humans; L Cells; Mice; Mice, SCID; Molecular Sequence Data; Neutrophils/immunology; Neutrophils/pathology; Platelet Endothelial Cell Adhesion Molecule-1/metabolism; Platelet Endothelial Cell Adhesion Molecule-1/physiology; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins/biosynthesis; Skin Transplantation/pathology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Immunoglobulins / Neutrophil Activation / Platelet Endothelial Cell Adhesion Molecule-1 / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Immunol Year: 2000 Document type: Article

Search on Google

XML

PubMed Links