Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor.

Kaul, D K; Tsai, H M; Liu, X D; Nakada, M T; Nagel, R L; Coller, B S

Kaul, D K; Tsai, H M; Liu, X D; Nakada, M T; Nagel, R L; Coller, B S.

Affiliation

Kaul DK; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA. kaul@aecom.yu.edu

Blood ; 95(2): 368-74, 2000 Jan 15.

Article in En | MEDLINE | ID: mdl-10627437

Subject(s)

Anemia, Sickle Cell/blood; Antibodies, Monoclonal/pharmacology; Cell Adhesion/physiology; Endothelium, Vascular/physiology; Erythrocytes/physiology; Immunoglobulin Fab Fragments/pharmacology; Platelet Activating Factor/pharmacology; Receptors, Vitronectin/physiology; Abciximab; Adult; Animals; Antibodies, Monoclonal, Humanized; Cecum/blood supply; Cell Adhesion/drug effects; Endothelium, Vascular/drug effects; Erythrocytes/drug effects; Erythrocytes/immunology; Humans; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors; Rats; Receptors, Vitronectin/immunology; Reference Values; Venules/physiology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Endothelium, Vascular / Platelet Activating Factor / Cell Adhesion / Receptors, Vitronectin / Erythrocytes / Anemia, Sickle Cell / Antibodies, Monoclonal Limits: Adult / Animals / Humans Language: En Journal: Blood Year: 2000 Document type: Article

Search on Google

XML

PubMed Links