Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets.

Hill, D J; Strutt, B; Arany, E; Zaina, S; Coukell, S; Graham, C F

Hill, D J; Strutt, B; Arany, E; Zaina, S; Coukell, S; Graham, C F.

Affiliation

Hill DJ; Lawson Research Institute, St. Joseph's Health Center, London, Ontario, Canada. dhill@lri.stjosephs.london.on.ca

Endocrinology ; 141(3): 1151-7, 2000 Mar.

Article in En | MEDLINE | ID: mdl-10698192

Subject(s)

Apoptosis/physiology; Insulin-Like Growth Factor II/physiology; Islets of Langerhans/physiology; Aging/metabolism; Animals; Animals, Newborn; Blood Glucose/metabolism; Cattle; DNA/biosynthesis; Immunohistochemistry; In Situ Nick-End Labeling; Insulin/metabolism; Insulin-Like Growth Factor I/metabolism; Insulin-Like Growth Factor II/metabolism; Islets of Langerhans/cytology; Islets of Langerhans/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger/biosynthesis; Radioimmunoassay

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Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor II / Islets of Langerhans / Apoptosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Endocrinology Year: 2000 Document type: Article

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