Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.

Rocheville, M; Lange, D C; Kumar, U; Patel, S C; Patel, R C; Patel, Y C

Rocheville, M; Lange, D C; Kumar, U; Patel, S C; Patel, R C; Patel, Y C.

Affiliation

Rocheville M; Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada.

Science ; 288(5463): 154-7, 2000 Apr 07.

Article in En | MEDLINE | ID: mdl-10753124

Subject(s)

Receptor Cross-Talk; Receptors, Dopamine D2/metabolism; Receptors, Somatostatin/metabolism; Animals; CHO Cells; Cell Membrane/metabolism; Cerebral Cortex/metabolism; Colforsin/pharmacology; Corpus Striatum/metabolism; Cricetinae; Cyclic AMP/metabolism; Dimerization; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Heterotrimeric GTP-Binding Proteins/metabolism; Humans; Ligands; Male; Neurons/metabolism; Pyramidal Cells/metabolism; Quinpirole/pharmacology; Rats; Receptors, Dopamine D2/agonists; Receptors, Dopamine D2/genetics; Receptors, Somatostatin/agonists; Receptors, Somatostatin/antagonists & inhibitors; Receptors, Somatostatin/genetics; Somatostatin/metabolism; Somatostatin/pharmacology; Spiperone/pharmacology; Sulpiride/pharmacology; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Somatostatin / Receptors, Dopamine D2 / Receptor Cross-Talk Limits: Animals / Humans / Male Language: En Journal: Science Year: 2000 Document type: Article

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