Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells.

Boffa, L C; Scarfi, S; Mariani, M R; Damonte, G; Allfrey, V G; Benatti, U; Morris, P L

Boffa, L C; Scarfi, S; Mariani, M R; Damonte, G; Allfrey, V G; Benatti, U; Morris, P L.

Affiliation

Boffa LC; National Cancer Institute, IST, Genoa, Italy.

Cancer Res ; 60(8): 2258-62, 2000 Apr 15.

Article in En | MEDLINE | ID: mdl-10786693

Subject(s)

Cell Nucleus/metabolism; Dihydrotestosterone/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Peptide Nucleic Acids/metabolism; Peptide Nucleic Acids/pharmacology; Prostatic Neoplasms/metabolism; Antisense Elements (Genetics)/genetics; Antisense Elements (Genetics)/metabolism; Antisense Elements (Genetics)/pharmacokinetics; Antisense Elements (Genetics)/pharmacology; Biological Transport; Cell Division/drug effects; Cell Survival/drug effects; Cytoplasm/metabolism; Genes, myc/genetics; Genetic Therapy; Humans; Male; Microscopy, Fluorescence; Nuclear Localization Signals; Peptide Nucleic Acids/chemistry; Peptide Nucleic Acids/pharmacokinetics; Prostatic Neoplasms/genetics; Prostatic Neoplasms/pathology; Prostatic Neoplasms/therapy; Receptors, Androgen/deficiency; Receptors, Androgen/genetics; Receptors, Androgen/metabolism; Substrate Specificity; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Dihydrotestosterone / Gene Expression Regulation, Neoplastic / Cell Nucleus / Peptide Nucleic Acids Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Cancer Res Year: 2000 Document type: Article

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