Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice.

Launay, P; Grossetête, B; Arcos-Fajardo, M; Gaudin, E; Torres, S P; Beaudoin, L; Patey-Mariaud de Serre, N; Lehuen, A; Monteiro, R C

Launay, P; Grossetête, B; Arcos-Fajardo, M; Gaudin, E; Torres, S P; Beaudoin, L; Patey-Mariaud de Serre, N; Lehuen, A; Monteiro, R C.

Affiliation

Launay P; Institut National de la Santé et de la Recherche Médicale U25, Necker Hospital, Paris 75743, France.

J Exp Med ; 191(11): 1999-2009, 2000 Jun 05.

Article in En | MEDLINE | ID: mdl-10839814

Subject(s)

Antigens, CD/immunology; Glomerulonephritis, IGA/immunology; Immunoglobulin A/immunology; Receptors, Fc/immunology; Animals; Antigens, CD/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/immunology; Female; Glomerulonephritis, IGA/pathology; Hematuria/immunology; Humans; Male; Mice; Mice, Knockout; Mice, SCID; Mice, Transgenic; Nuclear Proteins; Receptors, Fc/genetics; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin A / Receptors, Fc / Antigens, CD / Glomerulonephritis, IGA Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2000 Document type: Article

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