Low-molecular-weight heparin for thrombophilia in pregnant women.
Int J Gynaecol Obstet
; 69(3): 209-13, 2000 Jun.
Article
in En
| MEDLINE
| ID: mdl-10854861
ABSTRACT
OBJECTIVE:
Low-molecular-weight heparin (LMWH) is the anticoagulant of choice during pregnancy because it is associated with a low incidence of osteoporosis and thrombocytopenia. Antithrombotic therapy has recently been used to prevent pregnancy loss in high-risk patients with evidence of acquired or congenital thrombophilia. The aim of the present study was to gain further information on the teratogenic potential of LMWH in this patient group.METHODS:
The study population included 46 patients with a history of recurrent abortions, intrauterine fetal death or intrauterine growth restriction (IUGR) and severe early-onset preeclampsia. Patients with a history of thromboembolism or positive findings for thrombophilia were prescribed LMWH (enoxaparin sodium, 40 mg daily) in combination with low-dose aspirin (100 mg daily) in the first trimester (group 1, n=14) or the second trimester (group 2, n=17); the remaining 15 patients received low-dose aspirin alone (group 3).RESULTS:
No significant differences were noted between the groups in the incidence of congenital malformations or abortions, IUGR or preterm deliveries. One infant in group 1 had familial bilateral postaxial polydactyly of the hands and one in group 3 had patent ductus arteriosus.CONCLUSION:
Despite the small size of the study groups, our results support the assumption that the use of LMWH is safe, at least as a teratogenic agent, in patients with thrombophilia throughout pregnancy.
Search on Google
Collection:
01-internacional
Health context:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Database:
MEDLINE
Main subject:
Pregnancy Complications, Hematologic
/
Thromboembolism
/
Pregnancy Outcome
/
Aspirin
/
Heparin, Low-Molecular-Weight
/
Pregnancy, High-Risk
/
Thrombophilia
/
Fibrinolytic Agents
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Int J Gynaecol Obstet
Year:
2000
Document type:
Article