CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily.

Eliopoulos, A G; Davies, C; Knox, P G; Gallagher, N J; Afford, S C; Adams, D H; Young, L S

Eliopoulos, A G; Davies, C; Knox, P G; Gallagher, N J; Afford, S C; Adams, D H; Young, L S.

Affiliation

Eliopoulos AG; CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom. A.G.Eliopoulos@bham.ac.uk

Mol Cell Biol ; 20(15): 5503-15, 2000 Aug.

Article in En | MEDLINE | ID: mdl-10891490

Subject(s)

Apoptosis/physiology; CD40 Antigens/metabolism; Carcinoma/metabolism; Tumor Necrosis Factor-alpha/metabolism; Viral Proteins; Amino Acid Motifs; Apoptosis/drug effects; CD40 Antigens/genetics; CD40 Ligand; Carcinoma/pathology; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases/metabolism; Cycloheximide/pharmacology; Cysteine Proteinase Inhibitors/pharmacology; Fas Ligand Protein; Female; Humans; Ligands; Membrane Glycoproteins/genetics; Membrane Glycoproteins/immunology; Membrane Glycoproteins/metabolism; Serpins/metabolism; Signal Transduction; Tumor Cells, Cultured; fas Receptor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Carcinoma / Tumor Necrosis Factor-alpha / Apoptosis / CD40 Antigens Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Mol Cell Biol Year: 2000 Document type: Article

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