8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo.

Indolfi, C; Di Lorenzo, E; Rapacciuolo, A; Stingone, A M; Stabile, E; Leccia, A; Torella, D; Caputo, R; Ciardiello, F; Tortora, G; Chiariello, M

Indolfi, C; Di Lorenzo, E; Rapacciuolo, A; Stingone, A M; Stabile, E; Leccia, A; Torella, D; Caputo, R; Ciardiello, F; Tortora, G; Chiariello, M.

Affiliation

Indolfi C; Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy. Indolfi@unina.it

J Am Coll Cardiol ; 36(1): 288-93, 2000 Jul.

Article in En | MEDLINE | ID: mdl-10898448

Subject(s)

8-Bromo Cyclic Adenosine Monophosphate/analogs & derivatives; Antineoplastic Agents/pharmacology; Muscle, Smooth, Vascular/drug effects; Tunica Intima/drug effects; 8-Bromo Cyclic Adenosine Monophosphate/administration & dosage; 8-Bromo Cyclic Adenosine Monophosphate/pharmacology; Animals; Antineoplastic Agents/administration & dosage; Aorta, Thoracic/injuries; Aorta, Thoracic/pathology; Arterial Occlusive Diseases/enzymology; Arterial Occlusive Diseases/metabolism; Arterial Occlusive Diseases/prevention & control; Blood Pressure/drug effects; Catheterization/adverse effects; Cell Division/drug effects; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases/metabolism; Down-Regulation/drug effects; Heart Rate/drug effects; Injections, Intraperitoneal; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/enzymology; Rats; Rats, Wistar; Tunica Intima/cytology; Tunica Intima/enzymology; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: 8-Bromo Cyclic Adenosine Monophosphate / Tunica Intima / Muscle, Smooth, Vascular / Antineoplastic Agents Limits: Animals Language: En Journal: J Am Coll Cardiol Year: 2000 Document type: Article

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