Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.
Neurology
; 55(2): 309-11, 2000 Jul 25.
Article
in En
| MEDLINE
| ID: mdl-10908915
ABSTRACT
Several aspects of pyridoxine-dependent seizure (PDS) suggest a mutation affecting glutamate decarboxylase (GAD) as a possible cause. To examine the possibility of GAD linkage with PDS, the authors performed genotype analyses of three families using polymorphic markers near the GAD genes (GAD1 and GAD2). In each family, the affected siblings exhibited different genotypes for the GAD2 gene; in two families the GAD1 genotype was disparate. These findings suggest that a mutation of GAD is not directly involved in all cases of PDS.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridoxine
/
Vitamin B 6 Deficiency
/
Spasms, Infantile
/
Genotype
/
Glutamate Decarboxylase
/
Genetic Linkage
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
Neurology
Year:
2000
Document type:
Article