Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts.

Neidhart, M; Gay, R E; Gay, S

Neidhart, M; Gay, R E; Gay, S.

Affiliation

Neidhart M; WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University Hospital, Zurich, Switzerland.

Arthritis Rheum ; 43(8): 1719-28, 2000 Aug.

Article in En | MEDLINE | ID: mdl-10943861

Subject(s)

Arthritis, Rheumatoid/pathology; Cartilage, Articular/drug effects; Cartilage, Articular/metabolism; Fibroblasts/drug effects; Hyaluronan Receptors/immunology; Interleukin-1/antagonists & inhibitors; Animals; Antibodies, Monoclonal/pharmacology; Cattle; Cell Differentiation/drug effects; Chondrocytes/cytology; Cytokines/metabolism; Extracellular Matrix/physiology; Fibroblasts/metabolism; Humans; Mice; Mice, SCID; U937 Cells

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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Cartilage, Articular / Interleukin-1 / Hyaluronan Receptors / Fibroblasts Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Arthritis Rheum Year: 2000 Document type: Article

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