Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era.
Genomics
; 67(1): 78-82, 2000 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-10945472
ABSTRACT
Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like 1). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer.
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Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
RNA-Binding Proteins
/
GTP-Binding Proteins
/
Escherichia coli Proteins
/
Escherichia coli
/
GTP Phosphohydrolases
Limits:
Animals
/
Humans
Language:
En
Journal:
Genomics
Year:
2000
Document type:
Article