C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation.

Korematsu, S; Tanaka, Y; Hosoi, S; Koyanagi, S; Yokota, T; Mikami, B; Minato, N

Korematsu, S; Tanaka, Y; Hosoi, S; Koyanagi, S; Yokota, T; Mikami, B; Minato, N.

Affiliation

Korematsu S; Department of Immunology and Cell Biology, Graduate School of Medicine, and Research Institute for Food Science, Kyoto University, Kyoto, Japan.

J Immunol ; 165(5): 2895-902, 2000 Sep 01.

Article in En | MEDLINE | ID: mdl-10946323

Subject(s)

Allergens/genetics; Amino Acid Substitution/immunology; Glycoproteins/chemistry; Glycoproteins/genetics; Mites/immunology; Mutagenesis, Site-Directed; Th1 Cells/cytology; Th1 Cells/immunology; Adjuvants, Immunologic/genetics; Allergens/chemistry; Allergens/immunology; Allergens/metabolism; Amino Acid Substitution/genetics; Animals; Antigen Presentation/genetics; Antigens, Dermatophagoides; B-Lymphocytes/immunology; Cell Differentiation/genetics; Cell Differentiation/immunology; Clone Cells; Cysteine/genetics; Dose-Response Relationship, Immunologic; Epitopes, T-Lymphocyte/immunology; Glycoproteins/immunology; Glycoproteins/metabolism; Humans; Hypersensitivity, Immediate/blood; Hypersensitivity, Immediate/immunology; Lymphocyte Activation/genetics; Mites/genetics; Protein Structure, Secondary; Serine/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Allergens / Glycoproteins / Mutagenesis, Site-Directed / Th1 Cells / Amino Acid Substitution / Mites Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2000 Document type: Article

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