[Experimental models, of Parkinson disease]. / Modelos experimentales de enfermedad de Parkinson.
Rev Neurol
; 31(1): 60-6, 2000.
Article
in Es
| MEDLINE
| ID: mdl-10948587
ABSTRACT
This article reviews the most useful animal models of Parkinson's disease available. Basically they include the model of unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA) in rodents and the 1-methy-4-phenyl-1,2,3,6, tetrahydropyridine (MPTP) model of parkinsonism in non-human primates. The major neurochemical and histological alterations found in these two models are also analyzed. Finally, possible applications of these models of parkinsonism are also discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Disease Models, Animal
Limits:
Animals
/
Humans
Language:
Es
Journal:
Rev Neurol
Year:
2000
Document type:
Article