Dimerization of tissue factor supports solution-phase autoactivation of factor VII without influencing proteolytic activation of factor X.

Doñate, F; Kelly, C R; Ruf, W; Edgington, T S

Doñate, F; Kelly, C R; Ruf, W; Edgington, T S.

Affiliation

Doñate F; Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Biochemistry ; 39(37): 11467-76, 2000 Sep 19.

Article in En | MEDLINE | ID: mdl-10985793

Subject(s)

DNA-Binding Proteins; Factor VII/metabolism; Factor X/metabolism; Saccharomyces cerevisiae Proteins; Thrombin/metabolism; Thromboplastin/chemistry; Amides/metabolism; Cross-Linking Reagents; Dimerization; Factor VII/chemistry; Factor VIIa/chemistry; Factor VIIa/metabolism; Factor X/chemistry; Factor Xa/chemistry; Factor Xa/metabolism; Fungal Proteins/genetics; Fungal Proteins/metabolism; Humans; Hydrolysis; Leucine Zippers/genetics; Macromolecular Substances; Peptide Fragments/chemistry; Peptide Fragments/genetics; Peptide Fragments/metabolism; Protein Binding/genetics; Protein Conformation; Protein Kinases/genetics; Protein Kinases/metabolism; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/genetics; Solubility; Solutions; Thromboplastin/genetics; Thromboplastin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Factor VII / Factor X / Thromboplastin / Thrombin / Saccharomyces cerevisiae Proteins / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochemistry Year: 2000 Document type: Article

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