Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts.

Roberge, M; Cinel, B; Anderson, H J; Lim, L; Jiang, X; Xu, L; Bigg, C M; Kelly, M T; Andersen, R J

Roberge, M; Cinel, B; Anderson, H J; Lim, L; Jiang, X; Xu, L; Bigg, C M; Kelly, M T; Andersen, R J.

Affiliation

Roberge M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada. michel@otter.biochem.ubc.ca

Cancer Res ; 60(18): 5052-8, 2000 Sep 15.

Article in En | MEDLINE | ID: mdl-11016628

Subject(s)

Alkaloids/pharmacology; Antineoplastic Agents/pharmacology; Diterpenes; Drug Screening Assays, Antitumor/methods; Lactones/pharmacology; Paclitaxel/analogs & derivatives; Alkaloids/isolation & purification; Animals; Antibiotics, Antineoplastic/isolation & purification; Antibiotics, Antineoplastic/pharmacology; Antineoplastic Agents/isolation & purification; Antineoplastic Agents, Phytogenic/isolation & purification; Antineoplastic Agents, Phytogenic/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Enzyme-Linked Immunosorbent Assay; Humans; Invertebrates/chemistry; Lactones/isolation & purification; Macrolides; Marine Biology; Paclitaxel/isolation & purification; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Plants, Medicinal/chemistry; Pseudomonas/chemistry; Structure-Activity Relationship; Tissue Extracts/isolation & purification; Tissue Extracts/pharmacology; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Screening Assays, Antitumor / Paclitaxel / Diterpenes / Alkaloids / Lactones / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2000 Document type: Article

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