Retinal toxicity of triamcinolone acetonide in silicone-filled eyes.
Ophthalmic Surg Lasers
; 31(6): 474-8, 2000.
Article
in En
| MEDLINE
| ID: mdl-11095124
ABSTRACT
OBJECTIVE:
To determine the retinal toxicity of triamcinolone acetonide at different doses in vitrectomized, silicone-filled rabbit eyes. MATERIALS ANDMETHODS:
Vitrectomy with silicone oil placement was performed in 32 rabbit eyes. A dosage of 1 mg/0.025 mL, 2 mg/0.05 mL, or 4 mg/0.1 mL of triamcinolone acetonide was injected intravitreally in the study group eyes; the control group received 0.1 mL of sterile saline. Electroretinography and retinal histology were performed to evaluate toxicity.RESULTS:
No retinal toxicity was seen in the groups given 1, 2, and 4 mg of triamcinolone acetonide or in the control group. ERG and histologic sections in all groups were normal. No drug was visible in the vitreous cavity at the end of the 140-day period (average) in eyes injected with 4 mg of triamcinolone acetonide.CONCLUSIONS:
Up to 4 mg of triamcinolone acetonide can be safely injected in silicone-filled, vitrectomized eyes without any significant retinal toxicity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Vitrectomy
/
Silicone Oils
/
Triamcinolone Acetonide
/
Glucocorticoids
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Ophthalmic Surg Lasers
Year:
2000
Document type:
Article