Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.

Durley, R C; Grapperhaus, M L; Massa, M A; Mischke, D A; Parnas, B L; Fobian, Y M; Rath, N P; Honda, D D; Zeng, M; Connolly, D T; Heuvelman, D M; Witherbee, B J; Glenn, K C; Krul, E S; Smith, M E; Sikorski, J A

Durley, R C; Grapperhaus, M L; Massa, M A; Mischke, D A; Parnas, B L; Fobian, Y M; Rath, N P; Honda, D D; Zeng, M; Connolly, D T; Heuvelman, D M; Witherbee, B J; Glenn, K C; Krul, E S; Smith, M E; Sikorski, J A.

Affiliation

Durley RC; Pharmacia Discovery Research, 700 Chesterfield Parkway North, St. Louis, Missouri 63198, USA. richard.c.durley@monsanto.com

J Med Chem ; 43(24): 4575-8, 2000 Nov 30.

Article in En | MEDLINE | ID: mdl-11101348

Subject(s)

Carrier Proteins/chemistry; Cholesterol Esters/blood; Glycoproteins; Propanolamines/chemical synthesis; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/blood; Cholesterol Ester Transfer Proteins; Crystallography, X-Ray; Humans; In Vitro Techniques; Propanolamines/blood; Propanolamines/chemistry; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Propanolamines / Glycoproteins / Carrier Proteins / Cholesterol Esters Limits: Humans Language: En Journal: J Med Chem Year: 2000 Document type: Article

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