Glucose-dependent insulin release from genetically engineered K cells.

Cheung, A T; Dayanandan, B; Lewis, J T; Korbutt, G S; Rajotte, R V; Bryer-Ash, M; Boylan, M O; Wolfe, M M; Kieffer, T J

Cheung, A T; Dayanandan, B; Lewis, J T; Korbutt, G S; Rajotte, R V; Bryer-Ash, M; Boylan, M O; Wolfe, M M; Kieffer, T J.

Affiliation

Cheung AT; Department of Medicine, University of Alberta, Edmonton, AB T6G 2S2, Canada.

Science ; 290(5498): 1959-62, 2000 Dec 08.

Article in En | MEDLINE | ID: mdl-11110661

Subject(s)

Diabetes Mellitus, Experimental/therapy; Enteroendocrine Cells/cytology; Enteroendocrine Cells/metabolism; Genetic Therapy; Glucose/metabolism; Insulin/metabolism; Animals; Blood Glucose/metabolism; Cell Line; Cloning, Molecular; Diabetes Mellitus, Experimental/metabolism; Gastric Inhibitory Polypeptide/biosynthesis; Gastric Inhibitory Polypeptide/genetics; Gene Expression; Genetic Engineering; Glucose/administration & dosage; Glucose Tolerance Test; Humans; Insulin/biosynthesis; Insulin/genetics; Mice; Mice, Transgenic; Proinsulin/genetics; Promoter Regions, Genetic; Protein Precursors/genetics; Stem Cells/cytology; Stem Cells/metabolism; Streptozocin; Transfection; Transgenes; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Enteroendocrine Cells / Diabetes Mellitus, Experimental / Glucose / Insulin Limits: Animals / Humans Language: En Journal: Science Year: 2000 Document type: Article

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