Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.

Meng, Q; Yuan, F; Goldberg, I D; Rosen, E M; Auborn, K; Fan, S

Meng, Q; Yuan, F; Goldberg, I D; Rosen, E M; Auborn, K; Fan, S.

Affiliation

Meng Q; Department of Radiation Oncology and. Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.

J Nutr ; 130(12): 2927-31, 2000 Dec.

Article in En | MEDLINE | ID: mdl-11110848

Subject(s)

Breast Neoplasms/genetics; Estrogen Antagonists/pharmacology; Indoles/pharmacology; Receptors, Estrogen/metabolism; Breast Neoplasms/drug therapy; Breast Neoplasms/etiology; Cathepsin D/drug effects; Cathepsin D/genetics; Cathepsin D/metabolism; Dose-Response Relationship, Drug; Down-Regulation/drug effects; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic/drug effects; Genes, BRCA1/drug effects; Growth Inhibitors/metabolism; Humans; Proteins/drug effects; Proteins/genetics; Proteins/metabolism; Receptors, Estrogen/genetics; Sp1 Transcription Factor/drug effects; Sp1 Transcription Factor/genetics; Sp1 Transcription Factor/physiology; Transcription, Genetic/drug effects; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptors, Estrogen / Estrogen Antagonists / Indoles Type of study: Etiology_studies Limits: Female / Humans Language: En Journal: J Nutr Year: 2000 Document type: Article

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