Functional analysis of bone sialoprotein: identification of the hydroxyapatite-nucleating and cell-binding domains by recombinant peptide expression and site-directed mutagenesis.

Harris, N L; Rattray, K R; Tye, C E; Underhill, T M; Somerman, M J; D'Errico, J A; Chambers, A F; Hunter, G K; Goldberg, H A

Harris, N L; Rattray, K R; Tye, C E; Underhill, T M; Somerman, M J; D'Errico, J A; Chambers, A F; Hunter, G K; Goldberg, H A.

Affiliation

Harris NL; Department of Biochemistry, Faculty of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

Bone ; 27(6): 795-802, 2000 Dec.

Article in En | MEDLINE | ID: mdl-11113390

Subject(s)

Bone and Bones/chemistry; Durapatite/chemistry; Sialoglycoproteins/chemistry; Sialoglycoproteins/genetics; Amino Acid Sequence; Animals; Bone and Bones/metabolism; Calcification, Physiologic/physiology; Cells, Cultured; Crystallization; Fibroblasts/chemistry; Fibroblasts/cytology; Gene Expression/physiology; Gingiva/cytology; Humans; Integrin-Binding Sialoprotein; Molecular Sequence Data; Mutagenesis, Site-Directed/physiology; Oligopeptides/genetics; Oligopeptides/metabolism; Protein Structure, Tertiary; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/isolation & purification; Sialoglycoproteins/metabolism; Swine

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Sialoglycoproteins / Bone and Bones / Durapatite Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bone Year: 2000 Document type: Article

Search on Google

XML

PubMed Links