Potentiated opioid analgesia in norepinephrine transporter knock-out mice.

Bohn, L M; Xu, F; Gainetdinov, R R; Caron, M G

Bohn, L M; Xu, F; Gainetdinov, R R; Caron, M G.

Affiliation

Bohn LM; Howard Hughes Medical Institute, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

J Neurosci ; 20(24): 9040-5, 2000 Dec 15.

Article in En | MEDLINE | ID: mdl-11124980

Subject(s)

Analgesia; Carrier Proteins/genetics; Morphine/pharmacology; Narcotics/pharmacology; Symporters; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists/pharmacology; Adrenergic alpha-Antagonists/pharmacology; Animals; Antidepressive Agents, Tricyclic/pharmacology; Binding, Competitive/drug effects; Drug Synergism; Female; Male; Mice; Mice, Knockout; Narcotic Antagonists/pharmacology; Norepinephrine/metabolism; Norepinephrine Plasma Membrane Transport Proteins; Opioid Peptides/antagonists & inhibitors; Opioid Peptides/metabolism; Pain Measurement/drug effects; Pain Threshold/drug effects; Reaction Time/drug effects; Receptors, Adrenergic, alpha-2/metabolism; Receptors, Opioid, mu/antagonists & inhibitors; Receptors, Opioid, mu/metabolism; Spinal Cord/drug effects; Spinal Cord/immunology; Spinal Cord/metabolism; Spinal Cord/physiology; Spinal Cord/physiopathology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Symporters / Analgesia / Morphine / Narcotics Limits: Animals Language: En Journal: J Neurosci Year: 2000 Document type: Article

Fulltext

XML

PubMed Links

Search on Google