Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.

Thompson, A C; Zapata, A; Justice, J B; Vaughan, R A; Sharpe, L G; Shippenberg, T S

Thompson, A C; Zapata, A; Justice, J B; Vaughan, R A; Sharpe, L G; Shippenberg, T S.

Affiliation

Thompson AC; Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. act2@buffalo.edu

J Neurosci ; 20(24): 9333-40, 2000 Dec 15.

Article in En | MEDLINE | ID: mdl-11125013

Subject(s)

Benzeneacetamides; Cocaine/antagonists & inhibitors; Dopamine/pharmacokinetics; Membrane Glycoproteins; Membrane Transport Proteins; Naltrexone/analogs & derivatives; Nerve Tissue Proteins; Nucleus Accumbens/drug effects; Nucleus Accumbens/metabolism; Receptors, Opioid, kappa/metabolism; Analysis of Variance; Animals; Autoradiography; Carrier Proteins/metabolism; Cocaine/administration & dosage; Corpus Striatum/chemistry; Corpus Striatum/metabolism; Dopamine/analysis; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space/chemistry; Extracellular Space/metabolism; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Microdialysis; Naltrexone/administration & dosage; Nucleus Accumbens/chemistry; Pyrrolidines/administration & dosage; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa/agonists

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Membrane Glycoproteins / Dopamine / Cocaine / Receptors, Opioid, kappa / Benzeneacetamides / Naltrexone / Nerve Tissue Proteins / Nucleus Accumbens Limits: Animals Language: En Journal: J Neurosci Year: 2000 Document type: Article

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