Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.

Wen, R; Wang, D; McKay, C; Bunting, K D; Marine, J C; Vanin, E F; Zambetti, G P; Korsmeyer, S J; Ihle, J N; Cleveland, J L

Wen, R; Wang, D; McKay, C; Bunting, K D; Marine, J C; Vanin, E F; Zambetti, G P; Korsmeyer, S J; Ihle, J N; Cleveland, J L.

Affiliation

Wen R; Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Mol Cell Biol ; 21(2): 678-89, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11134353

Subject(s)

Gene Expression Regulation; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins/genetics; T-Lymphocytes/cytology; Animals; Apoptosis; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/metabolism; Cell Differentiation; Cell Survival; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; In Situ Nick-End Labeling; Janus Kinase 3; Mice; Mice, Knockout; Protein-Tyrosine Kinases/deficiency; Protein-Tyrosine Kinases/genetics; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; T-Lymphocytes/metabolism; Thymus Gland/cytology; Thymus Gland/growth & development; bcl-2-Associated X Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / T-Lymphocytes / Gene Expression Regulation / Proto-Oncogene Proteins / Proto-Oncogene Proteins c-bcl-2 Limits: Animals Language: En Journal: Mol Cell Biol Year: 2001 Document type: Article

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