The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation.

Meacham, G C; Patterson, C; Zhang, W; Younger, J M; Cyr, D M

Meacham, G C; Patterson, C; Zhang, W; Younger, J M; Cyr, D M.

Affiliation

Meacham GC; Department of Cell Biology and Cystic Fibrosis Center, University of Alabama Medical Center, 1918 University Boulevard, Birmingham, Alabama 35294-0005, USA.

Nat Cell Biol ; 3(1): 100-5, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11146634

Subject(s)

Carrier Proteins/metabolism; Cysteine Endopeptidases/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; HSP70 Heat-Shock Proteins/metabolism; Ligases; Molecular Chaperones/metabolism; Multienzyme Complexes/metabolism; Ubiquitin-Protein Ligases; Animals; Carrier Proteins/genetics; Cells, Cultured/cytology; Cells, Cultured/drug effects; Cells, Cultured/metabolism; Endoplasmic Reticulum/genetics; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/ultrastructure; Gene Deletion; Multienzyme Complexes/antagonists & inhibitors; Proteasome Endopeptidase Complex; Protein Folding; Protein Structure, Tertiary/physiology; Ubiquitins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Carrier Proteins / Molecular Chaperones / HSP70 Heat-Shock Proteins / Cystic Fibrosis Transmembrane Conductance Regulator / Ubiquitin-Protein Ligases / Ligases / Multienzyme Complexes Limits: Animals Language: En Journal: Nat Cell Biol Year: 2001 Document type: Article

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