The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.
Pharmacol Res
; 43(1): 17-22, 2001 Jan.
Article
in En
| MEDLINE
| ID: mdl-11207061
ABSTRACT
Our previous study indicated that the water layer present in Fructus Schisandra(FS(w)) at 10 and 25 mg kg(-1)significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FS(w)on CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FS(w)on CXM-induced amnesia was depressed by scopolamine. The serotonin releaser, p -chloroamphetamine significantly antagonized the ameliorating effect of FS(w)on CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT(1A)receptor agonist 8-OH-DPAT, but potentiated by the 5-HT(2)receptor antagonist ritanserin. Finally, the GABA(A)receptor antagonist bicuculline blocked the ameliorating effect of FS(w). These results suggest that the beneficial effect of FS(w)on CXM-induced amnesia is amplified by treatment with serotonergic 5-HT(2)receptor antagonists, but reduced by serotonergic 5-HT(1A)receptor agonists as well as GABA(A)and cholinergic receptor antagonists.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Polycyclic Compounds
/
Drugs, Chinese Herbal
/
Receptors, Neurotransmitter
/
Lignans
/
Cycloheximide
/
Cyclooctanes
/
Amnesia
/
Phytotherapy
Limits:
Animals
Language:
En
Journal:
Pharmacol Res
Year:
2001
Document type:
Article