Importance of attributable risk in monitoring adverse events after immunization: hepatitis B vaccination in children.
Am J Public Health
; 91(2): 313-5, 2001 Feb.
Article
in En
| MEDLINE
| ID: mdl-11211648
ABSTRACT
OBJECTIVES:
Most vaccine safety data present only the postvaccination incidence of all adverse events rather than an estimate of attributable risk. This study sought to illustrate the difference between the 2 estimates with data from a hepatitis B immunization program.METHODS:
The incidence of health problems occurring before and after each dose of hepatitis B vaccine in a cohort of 1130 children were compared.RESULTS:
Although 47.5% of all children reported an adverse event during the 4 weeks following each of the 3 doses, adverse events attributable to immunization occurred in only 10.6% of children.CONCLUSIONS:
Postimmunization incidence systematically overestimates the risk of adverse events. Estimating actual attributable risk is necessary to avoid false beliefs regarding immunization.
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Vaccines, Synthetic
/
Data Interpretation, Statistical
/
Drug Monitoring
/
Adverse Drug Reaction Reporting Systems
/
Hepatitis B Vaccines
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
Am J Public Health
Year:
2001
Document type:
Article