In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model.

Fennell, D A; Corbo, M V; Dean, N M; Monia, B P; Cotter, F E

Fennell, D A; Corbo, M V; Dean, N M; Monia, B P; Cotter, F E.

Affiliation

Fennell DA; Department of Experimental Haematology, St Bartholomew's and The Royal London School of Medicine & Dentistry, Turner Street, London E1 2AD, UK.

Br J Haematol ; 112(3): 706-13, 2001 Mar.

Article in En | MEDLINE | ID: mdl-11260076

Subject(s)

Drug Resistance, Neoplasm/genetics; Genetic Therapy/methods; Oligonucleotides, Antisense/administration & dosage; Proto-Oncogene Proteins c-bcl-2/genetics; Severe Combined Immunodeficiency/drug therapy; Animals; Apoptosis/drug effects; Caspase 3; Caspases/metabolism; Combined Modality Therapy; Enzyme Activation; Etoposide/pharmacology; Flow Cytometry/methods; Humans; Mice; Severe Combined Immunodeficiency/genetics; Severe Combined Immunodeficiency/metabolism; Transplantation, Heterologous; Tumor Cells, Cultured; bcl-X Protein

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Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Genetic Therapy / Oligonucleotides, Antisense / Severe Combined Immunodeficiency / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-bcl-2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Haematol Year: 2001 Document type: Article

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