beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

Pearson, E R; Velho, G; Clark, P; Stride, A; Shepherd, M; Frayling, T M; Bulman, M P; Ellard, S; Froguel, P; Hattersley, A T

Pearson, E R; Velho, G; Clark, P; Stride, A; Shepherd, M; Frayling, T M; Bulman, M P; Ellard, S; Froguel, P; Hattersley, A T.

Affiliation

Pearson ER; Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, Devon, UK.

Diabetes ; 50 Suppl 1: S101-7, 2001 Feb.

Article in En | MEDLINE | ID: mdl-11272165

Subject(s)

DNA-Binding Proteins; Diabetes Mellitus, Type 2/genetics; Genes/genetics; Islets of Langerhans/metabolism; Nuclear Proteins; Adult; Age Factors; Blood Glucose/metabolism; Diabetes Mellitus, Type 2/pathology; Diabetes Mellitus, Type 2/physiopathology; Family Health; Fasting; Female; Glucokinase/genetics; Glucose Tolerance Test; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Insulin/blood; Insulin Resistance; Islets of Langerhans/physiology; Male; Mutation; Proinsulin/blood; Transcription Factors/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Islets of Langerhans / Diabetes Mellitus, Type 2 / DNA-Binding Proteins / Genes Type of study: Prognostic_studies / Qualitative_research Limits: Adult / Female / Humans / Male Language: En Journal: Diabetes Year: 2001 Document type: Article

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