Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.

Matsumoto, M; Ogawa, W; Hino, Y; Furukawa, K; Ono, Y; Takahashi, M; Ohba, M; Kuroki, T; Kasuga, M

Matsumoto, M; Ogawa, W; Hino, Y; Furukawa, K; Ono, Y; Takahashi, M; Ohba, M; Kuroki, T; Kasuga, M.

Affiliation

Matsumoto M; Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

J Biol Chem ; 276(17): 14400-6, 2001 Apr 27.

Article in En | MEDLINE | ID: mdl-11278835

Subject(s)

Isoenzymes/chemistry; Mutation; Protein Kinase C/metabolism; Proto-Oncogene Proteins/metabolism; 3-Phosphoinositide-Dependent Protein Kinases; Adenoviridae/genetics; Adenoviridae/metabolism; Animals; Binding Sites; CHO Cells; Cell Line; Cricetinae; Enzyme Activation; Insulin/metabolism; Mice; Muscles/cytology; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation; Protein Binding; Protein Kinase C/chemistry; Protein Kinase C/physiology; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Signal Transduction

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Proto-Oncogene Proteins / Isoenzymes / Mutation Limits: Animals Language: En Journal: J Biol Chem Year: 2001 Document type: Article

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