Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv.

Heike, Y; Kasono, K; Kunisaki, C; Hama, S; Saijo, N; Tsuruo, T; Kuntz, D A; Rose, D R; Curiel, D T

Heike, Y; Kasono, K; Kunisaki, C; Hama, S; Saijo, N; Tsuruo, T; Kuntz, D A; Rose, D R; Curiel, D T.

Affiliation

Heike Y; UAB Gene Therapy Center, Wallace Tumor Institute, Birmingham, AL 35294-3300, USA.

Int J Cancer ; 92(1): 115-22, 2001 Apr 01.

Article in En | MEDLINE | ID: mdl-11279614

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/immunology; Antibodies, Monoclonal/genetics; Drug Resistance, Multiple; Immunoglobulin Fragments/genetics; Ovarian Neoplasms/immunology; ATP Binding Cassette Transporter, Subfamily B, Member 1/analysis; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Cell Division; Colony-Forming Units Assay; Cytoplasm/immunology; Doxorubicin/pharmacokinetics; Female; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Immunoglobulin Variable Region/genetics; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/metabolism; Rhodamine 123/pharmacokinetics; Transfection; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Immunoglobulin Fragments / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple / Antibodies, Monoclonal Limits: Female / Humans Language: En Journal: Int J Cancer Year: 2001 Document type: Article

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