Superantigen recognition by gammadelta T cells: SEA recognition site for human Vgamma2 T cell receptors.
Immunity
; 14(3): 331-44, 2001 Mar.
Article
in En
| MEDLINE
| ID: mdl-11290341
ABSTRACT
Human gammadelta T cells expressing the Vgamma2Vdelta2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens. We find that they also recognize staphylococcal enterotoxin A superantigens in a manner distinct from the recognition of nonpeptide antigens. Using chimeric and mutant toxins, SEA amino acid residues 20-27 were shown to be required for gammadelta TCR recognition of SEA. Residues at 200-207 that are critical for specific alphabeta TCR recognition of SEA do not affect gammadelta TCR recognition. SEA residues 20-27 are located in an area contiguous with the binding site of V beta chains. This study defines a superantigen recognition site for a gammadelta T cell receptor and demonstrates the differences between Vgamma2Vdelta2+ T cell recognition of superantigens and nonpeptide antigens.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Receptors, Antigen, T-Cell, gamma-delta
/
Superantigens
/
Enterotoxins
Limits:
Humans
Language:
En
Journal:
Immunity
Year:
2001
Document type:
Article