Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease.

Takahashi, J; Tanaka, J; Arai, K; Funata, N; Hattori, T; Fukuda, T; Fujigasaki, H; Uchihara, T

Takahashi, J; Tanaka, J; Arai, K; Funata, N; Hattori, T; Fukuda, T; Fujigasaki, H; Uchihara, T.

Affiliation

Takahashi J; Division of Neuropathology, The Jikei University School of Medicine, Tokyo, Japan.

J Neuropathol Exp Neurol ; 60(4): 369-76, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11305872

Subject(s)

Hyalin/metabolism; Inclusion Bodies/pathology; Neurodegenerative Diseases/pathology; Neurons/pathology; Proteins/metabolism; Adult; Ataxin-3; Ataxins; Cell Nucleus/metabolism; Cell Nucleus/pathology; Cell Nucleus/ultrastructure; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Disease Progression; Fatal Outcome; Female; Glutamine/genetics; Glutamine/metabolism; Humans; Hyalin/ultrastructure; Immunohistochemistry; Inclusion Bodies/metabolism; Inclusion Bodies/ultrastructure; Macromolecular Substances; Male; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurodegenerative Diseases/diagnosis; Neurodegenerative Diseases/metabolism; Neurons/metabolism; Neurons/ultrastructure; Nuclear Proteins; Proteins/genetics; Repressor Proteins; TATA-Box Binding Protein; Transcription Factors/genetics; Transcription Factors/metabolism; Trinucleotide Repeats/genetics; Ubiquitins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Inclusion Bodies / Neurodegenerative Diseases / Hyalin / Neurons Type of study: Diagnostic_studies / Risk_factors_studies Language: En Journal: J Neuropathol Exp Neurol Year: 2001 Document type: Article

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