Clinical review 129: Oral cholecystographic agents and the thyroid.
J Clin Endocrinol Metab
; 86(5): 1853-60, 2001 May.
Article
in En
| MEDLINE
| ID: mdl-11344170
ABSTRACT
Oral cholecystographic agents (OCAs) are known to affect thyroid hormone metabolism by acting as potent inhibitors of type I and type II deiodinases, blocking the conversion of T(4) to T(3) and rT(3) to T(2). In addition, iodine released from the drug blocks thyroid gland secretion of thyroid hormone. These properties make OCAs a potentially useful drug therapy in patients with hyperthyroidism and other thyrotoxic disorders. Short-term treatment with OCAs rapidly reduces serum T(3) levels, with a lesser effect on T(4) levels. OCAs are not useful for long-term treatment, which is usually followed by exacerbation of hyperthyroidism with continued use. The lack of significant side effects makes these drugs an excellent short-term option in situations where a rapid clinical improvement is critical.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Gland
/
Thyrotoxicosis
/
Cholecystography
/
Contrast Media
/
Iopanoic Acid
Limits:
Humans
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2001
Document type:
Article