Immunostimulant oxidized beta-glucan conjugates.
Int Immunopharmacol
; 1(3): 539-50, 2001 Mar.
Article
in En
| MEDLINE
| ID: mdl-11367537
ABSTRACT
beta-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many beta-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the beta-Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized beta-glucan and its conjugates with O-beta-alanyl-5-[6-(N,N'-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adjuvants, Immunologic
/
Glucans
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Int Immunopharmacol
Year:
2001
Document type:
Article