Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

Saha, D; Datta, P K; Beauchamp, R D

Saha, D; Datta, P K; Beauchamp, R D.

Affiliation

Saha D; Department of Surgery, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA.

J Biol Chem ; 276(31): 29531-7, 2001 Aug 03.

Article in En | MEDLINE | ID: mdl-11371552

Subject(s)

DNA-Binding Proteins/metabolism; Genes, ras; Signal Transduction/physiology; Trans-Activators/metabolism; Transcription, Genetic/drug effects; Transforming Growth Factor beta/pharmacology; Animals; Cell Division/drug effects; Cell Line, Transformed; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cell Transformation, Neoplastic; Gene Expression Regulation/drug effects; Genes, Tumor Suppressor; Genes, ras/drug effects; Isopropyl Thiogalactoside/pharmacology; Kinetics; Mutation; Protein Transport; Signal Transduction/drug effects; Thymidine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Signal Transduction / Trans-Activators / Transforming Growth Factor beta / Genes, ras / DNA-Binding Proteins Limits: Animals Language: En Journal: J Biol Chem Year: 2001 Document type: Article

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