7E3 F(ab')2, an effective antagonist of rat alphaIIbbeta3 and alphavbeta3, blocks in vivo thrombus formation and in vitro angiogenesis.

Sassoli, P M; Emmell, E L; Tam, S H; Trikha, M; Zhou, Z; Jordan, R E; Nakada, M T

Sassoli, P M; Emmell, E L; Tam, S H; Trikha, M; Zhou, Z; Jordan, R E; Nakada, M T.

Affiliation

Sassoli PM; Biology Research Centocor, Malvern, PA 19355, USA.

Thromb Haemost ; 85(5): 896-902, 2001 May.

Article in En | MEDLINE | ID: mdl-11372685

Subject(s)

Antibodies, Monoclonal/pharmacology; Immunoglobulin Fab Fragments/pharmacology; Neovascularization, Physiologic/drug effects; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors; Receptors, Vitronectin/antagonists & inhibitors; Thrombosis/drug therapy; Abciximab; Animals; Antibodies, Monoclonal/chemistry; Aorta/injuries; Aorta/pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Immunoglobulin Fab Fragments/chemistry; Kinetics; Male; Mice; Microcirculation; Platelet Aggregation/drug effects; Platelet Glycoprotein GPIIb-IIIa Complex/immunology; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Rats; Rats, Inbred Strains; Receptors, Vitronectin/immunology; Receptors, Vitronectin/metabolism; Thrombosis/prevention & control

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Immunoglobulin Fab Fragments / Receptors, Vitronectin / Platelet Glycoprotein GPIIb-IIIa Complex / Neovascularization, Physiologic / Antibodies, Monoclonal Limits: Animals Language: En Journal: Thromb Haemost Year: 2001 Document type: Article

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