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Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
Kang, S Y; Lee, K Y; Sung, S H; Park, M J; Kim, Y C.
Affiliation
  • Kang SY; College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.
J Nat Prod ; 64(5): 683-5, 2001 May.
Article in En | MEDLINE | ID: mdl-11374978
ABSTRACT
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.
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Collection: 01-internacional Database: MEDLINE Main subject: Plants, Medicinal / Cholinesterase Inhibitors / Coumarins Country/Region as subject: Asia Language: En Journal: J Nat Prod Year: 2001 Document type: Article
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Plants, Medicinal / Cholinesterase Inhibitors / Coumarins Country/Region as subject: Asia Language: En Journal: J Nat Prod Year: 2001 Document type: Article