Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism.

Hawighorst, T; Velasco, P; Streit, M; Hong, Y K; Kyriakides, T R; Brown, L F; Bornstein, P; Detmar, M

Hawighorst, T; Velasco, P; Streit, M; Hong, Y K; Kyriakides, T R; Brown, L F; Bornstein, P; Detmar, M.

Affiliation

Hawighorst T; Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

EMBO J ; 20(11): 2631-40, 2001 Jun 01.

Article in En | MEDLINE | ID: mdl-11387198

Subject(s)

Papilloma/prevention & control; Skin Neoplasms/prevention & control; Thrombospondins/physiology; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Adhesion Molecules/physiology; Cell Division; Disease Susceptibility; Endothelial Growth Factors/genetics; Female; Gene Expression Regulation, Neoplastic; Lymphokines/genetics; Mice; Mice, Inbred Strains; Mice, Knockout; Neovascularization, Pathologic/genetics; Neovascularization, Pathologic/physiopathology; Oligodeoxyribonucleotides, Antisense/pharmacology; Papilloma/chemically induced; Papilloma/genetics; Papilloma/pathology; Precancerous Conditions/chemically induced; Precancerous Conditions/genetics; Precancerous Conditions/pathology; Skin/drug effects; Skin/pathology; Skin Neoplasms/chemically induced; Skin Neoplasms/genetics; Skin Neoplasms/pathology; Thrombospondins/deficiency; Thrombospondins/genetics; Time Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Papilloma / Skin Neoplasms / Thrombospondins Type of study: Prognostic_studies Language: En Journal: EMBO J Year: 2001 Document type: Article

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