Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase.

Gottlob, K; Majewski, N; Kennedy, S; Kandel, E; Robey, R B; Hay, N

Gottlob, K; Majewski, N; Kennedy, S; Kandel, E; Robey, R B; Hay, N.

Affiliation

Gottlob K; Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

Genes Dev ; 15(11): 1406-18, 2001 Jun 01.

Article in En | MEDLINE | ID: mdl-11390360

Subject(s)

Apoptosis/physiology; Glycolysis/physiology; Hexokinase/metabolism; Mitochondria/metabolism; Protein Serine-Threonine Kinases/physiology; Proto-Oncogene Proteins/physiology; Animals; Apoptosis/genetics; Cells, Cultured; Cytochrome c Group/metabolism; Exoribonucleases/metabolism; Glucose/metabolism; Ion Channels/metabolism; Mitochondria/enzymology; Porins/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Voltage-Dependent Anion Channels; bcl-X Protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Apoptosis / Glycolysis / Hexokinase / Mitochondria Limits: Animals Language: En Journal: Genes Dev Year: 2001 Document type: Article

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