Effect of roxithromycin on eotaxin-primed reactive oxygen species from eosinophils.
Int Arch Allergy Immunol
; 125 Suppl 1: 38-41, 2001.
Article
in En
| MEDLINE
| ID: mdl-11408771
ABSTRACT
BACKGROUND:
The CC chemokine eotaxin not only attracts eosinophils to inflamed sites but also promotes adhesion, degranulation and reactive oxygen species production of eosinophils. Reactive oxygen species released from eosinophils are believed to injure epithelial cells at inflamed sites, resulting in airway hyperresponsiveness. Roxithromycin has been reported to have antiasthmatic effects, although its mechanism of action is not thoroughly understood. Therefore, the effect of roxithromycin on eotaxin-primed reactive oxygen species production from eosinophils was studied.METHODS:
Reactive oxygen species production by eosinophils cultured with or without roxithromycin was evaluated using luminol-dependent chemiluminescence.RESULTS:
Roxithromycin inhibited the release of reactive oxygen species from eosinophils evoked with the calcium ionophore A23187, regardless of pretreatment with or without eotaxin.CONCLUSION:
Roxithromycin may protect epithelial cells at inflamed sites, at least partly by inhibiting the release of reactive oxygen species from eosinophils.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Roxithromycin
/
Cytokines
/
Reactive Oxygen Species
/
Anti-Asthmatic Agents
/
Chemokines, CC
/
Eosinophils
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int Arch Allergy Immunol
Year:
2001
Document type:
Article