Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey.
J Hypertens
; 19(7): 1209-15, 2001 Jul.
Article
in En
| MEDLINE
| ID: mdl-11446710
ABSTRACT
OBJECTIVE:
To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes.DESIGN:
Prospective cohort study.SETTING:
Work site in Osaka, Japan.PARTICIPANTS:
A total of 6,356 Japanese men, aged 35-60 years with systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg, normal glucose intolerance, and no history of hypertension or diabetes at baseline. MAIN OUTCOMEMEASURES:
Blood pressure was measured by standard techniques, using 160/95 mmHg for diagnosis of hypertension. Type 2 diabetes was defined as a fasting plasma glucose level > or = 126 mg/dl or a 2 h post-loaded plasma glucose level > or = 200 mg/dl.RESULTS:
During the 61,716 person-years follow-up period, we confirmed 639 cases of hypertension and 454 cases of Type 2 diabetes. Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes. After adjustment for known risk factors, including daily alcohol consumption, the serum uric acid level was associated with an increased risk for hypertension; the relative risks for hypertension were 1.00 for quintile 1 of the serum uric acid level, 1.24 [95% confidence interval (CI), 0.94-1.65] for quintile 2, 1.34 (CI, 1.03-1.76) for quintile 3, 1.76 (CI, 1.35-2.29) for quintile 4, and 2.01 (CI, 1.56-2.60) for quintile 5 (P for trend < 0.001). Even among both non-drinkers and lean subjects, serum uric acid level was associated with an increased risk for hypertension.CONCLUSIONS:
Serum uric acid level was associated with an increased risk for hypertension but not for Type 2 diabetes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uric Acid
/
Health Surveys
/
Asian People
/
Diabetes Mellitus, Type 2
/
Hypertension
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Hypertens
Year:
2001
Document type:
Article