Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists.

DiPardo, R M; Patane, M A; Newton, R C; Price, R; Broten, T P; Chang, R S; Ransom, R W; Di Salvo, J; Freidinger, R M; Bock, M G

DiPardo, R M; Patane, M A; Newton, R C; Price, R; Broten, T P; Chang, R S; Ransom, R W; Di Salvo, J; Freidinger, R M; Bock, M G.

Affiliation

DiPardo RM; Department of Medicinal Chemistry, Merck & Co., Inc., 19486, West Point, PA, USA.

Bioorg Med Chem Lett ; 11(14): 1959-62, 2001 Jul 23.

Article in En | MEDLINE | ID: mdl-11459670

Subject(s)

Adrenergic alpha-1 Receptor Antagonists; Animals; Dogs; Half-Life; Imides/blood; Imides/chemical synthesis; Imides/pharmacokinetics; Male; Piperidines/chemical synthesis; Piperidines/pharmacokinetics; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Adrenergic alpha-1 Receptor Antagonists Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Year: 2001 Document type: Article

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