Cell death in spinal cord injury (SCI) requires de novo protein synthesis. Calpain inhibitor E-64-d provides neuroprotection in SCI lesion and penumbra.

Ray, S K; Matzelle, D D; Wilford, G G; Hogan, E L; Banik, N L

Ray, S K; Matzelle, D D; Wilford, G G; Hogan, E L; Banik, N L.

Affiliation

Ray SK; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Ann N Y Acad Sci ; 939: 436-49, 2001 Jun.

Article in En | MEDLINE | ID: mdl-11462799

Subject(s)

Apoptosis/drug effects; Glycoproteins/pharmacology; Leucine/analogs & derivatives; Leucine/pharmacology; Protease Inhibitors/pharmacology; Spinal Cord Injuries/metabolism; Animals; Apoptosis/physiology; Calpain/metabolism; Cell Death/drug effects; Cell Death/physiology; Cycloheximide/therapeutic use; Female; Glycoproteins/therapeutic use; Leucine/therapeutic use; Protease Inhibitors/therapeutic use; Protein Synthesis Inhibitors/therapeutic use; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries/drug therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Spinal Cord Injuries / Glycoproteins / Apoptosis / Leucine Limits: Animals Language: En Journal: Ann N Y Acad Sci Year: 2001 Document type: Article

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