Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.

Staples, K J; Bergmann, M; Tomita, K; Houslay, M D; McPhee, I; Barnes, P J; Giembycz, M A; Newton, R

Staples, K J; Bergmann, M; Tomita, K; Houslay, M D; McPhee, I; Barnes, P J; Giembycz, M A; Newton, R.

Affiliation

Staples KJ; Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom.

J Immunol ; 167(4): 2074-80, 2001 Aug 15.

Article in En | MEDLINE | ID: mdl-11489990

Subject(s)

Cyclic AMP-Dependent Protein Kinases/physiology; Cyclic AMP/physiology; Immunosuppressive Agents/pharmacology; Interleukin-5/antagonists & inhibitors; Sulfonamides; T-Lymphocytes/enzymology; T-Lymphocytes/immunology; 8-Bromo Cyclic Adenosine Monophosphate/pharmacology; Cells, Cultured; Cholera Toxin/pharmacology; Colforsin/pharmacology; Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors; Cyclic AMP Response Element-Binding Protein/metabolism; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Guanine Nucleotide Exchange Factors/pharmacology; Humans; Interleukin-5/biosynthesis; Isoquinolines/pharmacology; Lymphocyte Activation/drug effects; Phosphorylation/drug effects; Rolipram/pharmacology; T-Lymphocytes/drug effects; T-Lymphocytes/metabolism; rap1 GTP-Binding Proteins/metabolism

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Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Sulfonamides / T-Lymphocytes / Interleukin-5 / Cyclic AMP-Dependent Protein Kinases / Cyclic AMP / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Immunol Year: 2001 Document type: Article

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