Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.
Blood
; 98(4): 1142-9, 2001 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-11493463
ABSTRACT
The cellular mechanisms that configure the cytoskeleton during migration of dendritic cells (DCs) are poorly understood. Immature DCs assemble specialized adhesion structures known as podosomes at their leading edge; these are associated with the localized recruitment of the Wiskott-Aldrich Syndrome protein (WASp) and the actin organizing actin-related protein 2/3 complex. In immature DCs lacking WASp, podosomes are absent, residual dysmorphic lamellipodia and filopodia are nonpolarized, and migration is severely compromised. Microinjection studies indicate that podosome assembly and polarization require concerted action of Cdc42, Rac, and Rho, thereby providing a link between sequential protrusive and adhesive activity. Formation of podosomes is restricted to cells with an immature phenotype, indicating a specific role for these structures during the early migratory phase. (Blood. 2001;981142-1149)
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytoskeleton
/
Dendritic Cells
/
Proteins
/
Rho GTP-Binding Proteins
/
Cytoskeletal Proteins
Limits:
Humans
Language:
En
Journal:
Blood
Year:
2001
Document type:
Article