The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock.

Zacharowski, K; Berkels, R; Olbrich, A; Chatterjee, P K; Cuzzocrea, S; Foster, S J; Thiemermann, C

Zacharowski, K; Berkels, R; Olbrich, A; Chatterjee, P K; Cuzzocrea, S; Foster, S J; Thiemermann, C.

Affiliation

Zacharowski K; William Harvey Research Institute, St. Bartholomew's and The Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom. k.zacharowski@mds.qmw.ac.uk

Crit Care Med ; 29(8): 1599-608, 2001 Aug.

Article in En | MEDLINE | ID: mdl-11505136

Subject(s)

Enzyme Inhibitors/therapeutic use; Escherichia coli Infections/drug therapy; Guanylate Cyclase/antagonists & inhibitors; Multiple Organ Failure/prevention & control; Oxadiazoles/therapeutic use; Quinoxalines/therapeutic use; Shock, Septic/drug therapy; Staphylococcal Infections/drug therapy; Animals; Cells, Cultured; Escherichia coli Infections/complications; Hemodynamics/drug effects; Hydrogen Peroxide/antagonists & inhibitors; Hydrogen Peroxide/toxicity; Kidney/drug effects; Kidney/pathology; Liver/drug effects; Liver/enzymology; Lung/drug effects; Lung/pathology; Male; Multiple Organ Failure/etiology; Multiple Organ Failure/metabolism; Rats; Rats, Wistar; Shock, Septic/complications; Staphylococcal Infections/complications

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Collection: 01-internacional Health context: 2_ODS3 / 3_ND Database: MEDLINE Main subject: Oxadiazoles / Quinoxalines / Shock, Septic / Staphylococcal Infections / Enzyme Inhibitors / Escherichia coli Infections / Guanylate Cyclase / Multiple Organ Failure Type of study: Etiology_studies Limits: Animals Language: En Journal: Crit Care Med Year: 2001 Document type: Article

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